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- KD/KO Validated
Fibrinogen Gamma Chain Polyclonal antibody
Fibrinogen Gamma Chain Polyclonal Antibody for IHC, WB,ELISA
Cat no : 15841-1-AP
|Positive WB detected in||human spleen tissue, human liver tissue|
|Positive IHC detected in||human hepatocirrhosis tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:10000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
15841-1-AP targets Fibrinogen Gamma Chain in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fibrinogen Gamma Chain fusion protein Ag8597|
|Full Name||fibrinogen gamma chain|
|Calculated molecular weight||453aa,52 kDa; 437aa,50 kDa|
|Observed molecular weight||52 kDa|
|GenBank accession number||BC007044|
|Gene ID (NCBI)||2266|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.
Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.
J Thromb Haemost
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) cross-linking via tissue transglutaminase.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.
FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model.
Fibrinogen Chains Intrinsic to the Brain.
Cell Mol Neurobiol
Myelin Debris Impairs Tight Junctions and Promotes the Migration of Microvascular Endothelial Cells in the Injured Spinal Cord.