Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
13747-1-AP targets GADD45A in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||GADD45A fusion protein Ag4687|
|Full Name||growth arrest and DNA-damage-inducible, alpha|
|Calculated molecular weight||165 aa, 18 kDa|
|GenBank accession number||BC011757|
|Gene ID (NCBI)||1647|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
GADD45A, also named as DDIT1 and GADD45, belongs to the GADD45 family. It binds to proliferating cell nuclear antigen. GADD45A may affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. GADD45A plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. GADD45A has Dimer (~28-36 kDa) and Monomer (14-18 kDa) forms (PMID:11498536).
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma
Int J Nanomedicine
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Down-regulation of GADD45A enhances chemosensitivity in melanoma.
J Exp Clin Cancer Res
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.
J Cell Physiol
miR-124 and miR-9 Mediated Downregulation of HDAC5 Promotes Neurite Development Through Activating MEF2C- GPM6A Pathway.