GALR2 Polyclonal antibody, PBS Only

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• GALR2 Polyclonal antibody, PBS Only (29909-1-PBS)

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  WB analysis using 29909-1-AP (same clone as 29909-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29909-1-AP (GALR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 29909-1-AP (same clone as 29909-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using GALR2 antibody (29909-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

GALR2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Cat No. 29909-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

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Product Information

29909-1-PBS targets GALR2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag31762

  Product name: Recombinant human GALR2 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 287-387 aa of NM_003857

  Sequence: VNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA

• Full Name: galanin receptor 2
• Calculated Molecular Weight: 42KD
• Observed Molecular Weight: 42-50 kDa
• GenBank Accession Number: NM_003857
• Gene Symbol: GALR2
• Gene ID (NCBI): 8811
• RRID: AB_2935488
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O43603
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Galanin receptor type 2 (GALR2) is a receptor for galanin, GALP, and the hormone SPX1 (PMID:24517231). It is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamo-pituitary axis. Activation of the GALR2 may protect the hippocampus from neuronal damage (PMID: 17263796). It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibits adenylyl cyclase. GALR2 has a calculated molecular weight of 42 kDa.