GDI1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55214-1-AP

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Freight/Packing

Con: 58 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SH-SY5Y cells, human brain tissue, mouse brain tissue, SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
GDP dissociation inhibitor 1

Calculated molecular weight:
51 kDa

Observed molecular weight:
51-55kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GDI1

Synonyms
GDI1, MRX41, GDP dissociation inhibitor 1, GDIL, GDI 1
Background

GDP dissociation inhibitors (GDIs) are proteins that regulate the GDP-GTP exchange reaction of members of the rab family. GDIs can bind and release GDP-bound Rab proteins from membranes. Two GDI proteins towards different Rab proteins have been identified. GDI1 interacts with almost all of the Rab proteins, while GDI2 interacts with Rabll but not Rab3A. GDI1 is expressed primarily in neural and sensory tissues and also in secretory cells, displaying a diffuse, cytoplasmic distribution in cells. It runs as a 55kda protein in SDS-PAGE. (PMID: 7929030,PMID: 19570034). Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41). Defects in GDI1 are the cause of mental retardation X-linked type 48 (MRX48). The antibody is specific to GDI1. And it has no cross reaction to GDI2.


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