Product Information
29617-1-PBS targets GEN1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag31227 Product name: Recombinant human GEN1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 730-908 aa of NM_182625 Sequence: NESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST Predict reactive species |
| Full Name | Gen homolog 1, endonuclease (Drosophila) |
| Calculated Molecular Weight | 103 kDa |
| Observed Molecular Weight | 110 kDa |
| GenBank Accession Number | NM_182625 |
| Gene Symbol | GEN1 |
| Gene ID (NCBI) | 348654 |
| RRID | AB_3086145 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q17RS7 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
GEN1 is a endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. GEN1 efficiently cleaves both single and double HJs contained within large recombination intermediates.
