Product Information
12758-1-PBS targets GNAZ in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag3255 Product name: Recombinant human GNAZ protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-355 aa of BC026342 Sequence: MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEACKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPDRAYDAVQLFALTGPAESKGEITPELLGVMRRLWADQGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLAEKIRRIPLTICFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGLC Predict reactive species |
| Full Name | guanine nucleotide binding protein (G protein), alpha z polypeptide |
| Calculated Molecular Weight | 355 aa, 41 kDa |
| Observed Molecular Weight | 38-41 kDa |
| GenBank Accession Number | BC026342 |
| Gene Symbol | GNAZ |
| Gene ID (NCBI) | 2781 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P19086 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Guanine nucleotide-binding protein G(z) subunit alpha(GNAZ) is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. Heterotrimeric G proteins consist of alpha (α), beta (β), and gamma (γ) subunits. G proteins act as molecular switches inside cells, functioning to relay and transmit signals from cell surface receptors to intracellular effectors(PMID: 35052777). GNAS transduces signals from G protein-coupled receptors (GPCR) to adenyl cyclase (AC), and finally regulates the expression of cyclic adenosine monophosphate (cAMP)(PMID: 32700107).
