|Positive WB detected in||human liver tissue, human brain tissue, Transfected HEK-293 cells|
|Positive IHC detected in||human liver cancer tissue, human brain tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
13501-1-AP targets GPX7 in WB, IHC, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||chicken, human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||GPX7 fusion protein Ag4328|
|Full Name||glutathione peroxidase 7|
|Calculated molecular weight||187 aa, 21 kDa|
|Observed molecular weight||21 kDa|
|GenBank accession number||BC032788|
|Gene ID (NCBI)||2882|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
GPX7(Glutathione peroxidase 7) is also named as GPX6,CL683,GSHPx-7 and belongs to the glutathione peroxidase family.It shares approximately 45% amino acid sequence with other GPX family members.Because GPX7 expression protected cells from acidic bile acidinduced DNA damage, it may protect oesophageal epithelial cells from acidic bile acid-induced apoptosis(PMID:22157330).
Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer.
The development of antioxidant system in the intestinal tract of broiler chickens.
Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis.
GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress.
Free Radic Biol Med
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum.
Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesi.