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GPX7 Polyclonal antibody
GPX7 Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
human and More (2)
WB, IHC, IF, ELISA
Cat no : 13501-1-AP
Validation Data Gallery
|Positive WB detected in||human liver tissue, human placenta tissue, human brain tissue, Transfected HEK-293 cells|
|Positive IHC detected in||human liver cancer tissue, human brain tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 3 publications below|
|WB||See 10 publications below|
|IHC||See 3 publications below|
|IF||See 1 publications below|
13501-1-AP targets GPX7 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||GPX7 fusion protein Ag4328|
|Full Name||glutathione peroxidase 7|
|Calculated molecular weight||187 aa, 21 kDa|
|Observed molecular weight||18-21 kDa|
|GenBank accession number||BC032788|
|Gene ID (NCBI)||2882|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
GPX7(Glutathione peroxidase 7) is also named as GPX6,CL683,GSHPx-7 and belongs to the glutathione peroxidase family.It shares approximately 45% amino acid sequence with other GPX family members.Because GPX7 expression protected cells from acidic bile acidinduced DNA damage, it may protect oesophageal epithelial cells from acidic bile acid-induced apoptosis(PMID:22157330). This antibody can ve detected as 18-21kDa due to signal peptide splicing.
|Product Specific Protocols|
|WB protocol for GPX7 antibody 13501-1-AP||Download protocol|
|IHC protocol for GPX7 antibody 13501-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.
Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.
EMBO Mol Med
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling.
Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesi.
Free Radic Biol Med
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum.