NMDAR2B/GRIN2B Monoclonal antibody
NMDAR2B/GRIN2B Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Human, Mouse, Rat
Cat no : 66565-1-Ig
|Positive WB detected in
|mouse brain tissue, rat brain tissue
|Western Blot (WB)
|WB : 1:1000-1:6000
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
66565-1-Ig targets NMDAR2B/GRIN2B in WB, ELISA applications and shows reactivity with Human, Mouse, Rat samples.
|Human, Mouse, Rat
|Host / Isotype
|Mouse / IgG1
|NMDAR2B/GRIN2B fusion protein Ag16718
|glutamate receptor, ionotropic, N-methyl D-aspartate 2B
|Calculated molecular weight
|1484 aa, 166 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Protein G purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Lisa (Verified Customer) (10-04-2021)
The antibody signal is not very strong and specific on hiPSCs derived neurons: it is detectable with an exposure of about 90 seconds, but sometimes gives aspecific bands