NMDAR2B/GRIN2B Monoclonal antibody

NMDAR2B/GRIN2B Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

1C5E12

Cat no : 66565-1-Ig

Synonyms

GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3



Tested Applications

Positive WB detected inmouse brain tissue, rat brain tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
Sample-dependent, check data in validation data gallery

Product Information

66565-1-Ig targets NMDAR2B/GRIN2B in WB,ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NMDAR2B/GRIN2B fusion protein Ag16718
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Calculated molecular weight 1484 aa, 166 kDa
Observed molecular weight 166 kDa
GenBank accession numberBC113620
Gene symbol GRIN2B
Gene ID (NCBI) 2904
Conjugate Unconjugated
Form Liquid
Purification Method Protein G purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Protocols

Product Specific Protocols
WB protocol for NMDAR2B/GRIN2B antibody 66565-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols