HERV-FRD Polyclonal antibody

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• HERV-FRD Polyclonal antibody (18101-1-AP)

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  WB analysis using 18101-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 18101-1-AP (HERV-FRD antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

HERV-FRD Polyclonal Antibody for WB, ELISA

Cat No. 18101-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Envelope polyprotein, ERVFRDE1, GLLL6191, HERV FRD, SU Transmembrane protein

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Tested Applications

• Positive WB detected in: HepG2 cells, L02 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

18101-1-AP targets HERV-FRD in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag12380

  Product name: Recombinant human HERV-FRD protein

  Source: e coli.-derived, T-HIS

  Tag: 6*His

  Domain: 14-353 aa of BC068585

  Sequence: LAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSPLPRVRRAIH

• Full Name: HERV-FRD provirus ancestral Env polyprotein
• Calculated Molecular Weight: 538 aa, 60 kDa
• Observed Molecular Weight: 60 kDa
• GenBank Accession Number: BC068585
• Gene Symbol: HERV-FRD
• Gene ID (NCBI): 405754
• RRID: AB_3741946
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P60508
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

HERV-FRD (Human Endogenous Retrovirus FRD Envelope Protein) belongs to the W family of the HERV family. Also known as Syncytin-2, this protein is a key member of the syncytin family and is encoded by an env gene from an ancient retrovirus integrated into the host genome. It primarily mediates cell-cell fusion, which is essential for forming the placental syncytiotrophoblast and maintaining normal pregnancy. Furthermore, HERV-FRD exhibits immunosuppressive functions: its transmembrane subunit contains an immunosuppressive domain that inhibits maternal immune rejection of the fetus and protects the placenta from immune attack. Abnormal expression of HERV-FRD is associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction, as well as with the development and progression of certain cancers.