Product Information
18101-1-PBS targets HERV-FRD in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag12380 Product name: Recombinant human HERV-FRD protein Source: e coli.-derived, T-HIS Tag: 6*His Domain: 14-353 aa of BC068585 Sequence: LAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSTVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSPLPRVRRAIH Predict reactive species |
| Full Name | HERV-FRD provirus ancestral Env polyprotein |
| Calculated Molecular Weight | 538 aa, 60 kDa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | BC068585 |
| Gene Symbol | HERV-FRD |
| Gene ID (NCBI) | 405754 |
| RRID | AB_3741946 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P60508 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
HERV-FRD (Human Endogenous Retrovirus FRD Envelope Protein) belongs to the W family of the HERV family. Also known as Syncytin-2, this protein is a key member of the syncytin family and is encoded by an env gene from an ancient retrovirus integrated into the host genome. It primarily mediates cell-cell fusion, which is essential for forming the placental syncytiotrophoblast and maintaining normal pregnancy. Furthermore, HERV-FRD exhibits immunosuppressive functions: its transmembrane subunit contains an immunosuppressive domain that inhibits maternal immune rejection of the fetus and protects the placenta from immune attack. Abnormal expression of HERV-FRD is associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction, as well as with the development and progression of certain cancers.
