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HLA-DMB Recombinant antibody, PBS Only

HLA-DMB Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

230123A3

Cat no : 82922-1-PBS

Synonyms

D6S221E, DMB, HLA DMB, HLA-DMB, MHC class II antigen DMB, RING7

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using HLA-DMB Recombinant antibody (82922-1-RR)

    WB analysis using 82922-1-RR (same clone as 82922-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 82922-1-RR (HLA-DMB antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82922-1-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

82922-1-PBS targets HLA-DMB in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen HLA-DMB fusion protein Ag16320
Full Name major histocompatibility complex, class II, DM beta
Calculated Molecular Weight 263 aa, 29 kDa
Observed Molecular Weight31 kDa
GenBank Accession NumberBC027175
Gene Symbol HLA-DMB
Gene ID (NCBI) 3109
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). The class II molecules are composed of two non-covalently associated alpha and beta chains. HLA-DMA and HLA-DMB form a functional heterodimer that is critical in the pathway of class II antigen presentation. HLA-DM plays a critical role in catalyzing the release of Class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.