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|Cell culture supernatant||90%||74%-105%|
The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. C1q plays an important role in complement activation by immune complexes. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis.