Mouse ICAM5 Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 85941-1-RR (same clone as 85941-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85941-1-RR (Icam5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85941-1-PBS in a different storage buffer formulation.

• 

  IP experiment of mouse brain using 85941-1-RR (same clone as 85941-1-PBS)

  IP result of anti-ICAM5 (IP:85941-1-RR, 4ug; Detection:85941-1-RR 1:4000) with mouse brain tissue lysate 2120 ug. This data was developed using the same antibody clone with 85941-1-PBS in a different storage buffer formulation.

ICAM5 Uni-rAb^® Recombinant Antibody for WB, IP, Indirect ELISA

Cat No. 85941-1-PBS

Clone No.243100H5

Host / Isotype

Rabbit / IgG

Reactivity

mouse, rat

Applications

WB, IP, Indirect ELISA

Synonyms

Icam3, ICAM-5, Intercellular adhesion molecule 5, Telencephalin, Tlcn

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Product Information

85941-1-PBS targets ICAM5 in WB, IP, Indirect ELISA applications and shows reactivity with mouse, rat samples.

• Tested Reactivity: mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2868

  Product name: recombinant mouse Icam5 protein

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 32-832 aa of N/A

  Sequence: EPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPSWQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRSFVGEPPRARGAMLTARVLARREDHRVNFSCLAELDLRPHGLGLFANSSAPRQLRTFAMPPHSPSLIAPRVLEVDSERPVTCTLDGLFPAPEAGVYLSLGDQRLNPNVTLDGDSLVATATATASAEQEGTKQLMCVVTLGGESRETQENLTVYSFPTPLLTLSEPEAPEGKMVTISCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVDGETLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPEGGAVLALGLLGPVTRALAGTYRCTAVNGQGQAVKDVTLTVEYAPALDSVGCPEHITWLEGTEASLSCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAVTVEYGPSFEELGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGIVLPLVSSNSGPRNSMTPGNLSPGIYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGAEATALACSARGRPSPRVHCSREGAARLERLQVSREDAGTYRCVATNAHGTDSRTVTVGVEYRPVVAELAASPPSVRPGGNFTLTCRAEAWPPAQISWRAPPGALNLGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP

• Full Name: intercellular adhesion molecule 5, telencephalin
• Calculated Molecular Weight: 97 kDa
• Observed Molecular Weight: 150 kDa
• GenBank Accession Number: N/A
• Gene Symbol: Icam5
• Gene ID (NCBI): 15898
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q60625.1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases. (PMID: 10402269; 17682049; 25300135)