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- KD/KO Validated
ICMT Polyclonal antibody
ICMT Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 51001-2-AP
Synonyms
Validation Data Gallery
Published Applications
| KD/KO | See 3 publications below |
| WB | See 5 publications below |
Product Information
51001-2-AP targets ICMT in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | isoprenylcysteine carboxyl methyltransferase |
| Calculated Molecular Weight | 284 aa, 32 kDa |
| Observed Molecular Weight | 30-34 kDa |
| GenBank Accession Number | BC028168 |
| Gene Symbol | ICMT |
| Gene ID (NCBI) | 23463 |
| RRID | AB_2122574 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Publications
| Species | Application | Title |
|---|---|---|
J Clin Invest Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
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J Cell Biol Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
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Oncotarget Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. | ||
Life Sci Alliance NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.
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J Biol Chem Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor. |
Reviews
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Kishor (Verified Customer) (12-13-2018) |
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