Anti-Human IL-15RA Rabbit Recombinant Antibody, PBS Only

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• Anti-Human IL-15RA Rabbit Recombinant Antibody, PBS Only (98380-3-PBS)

IL-15RA Uni-rAb^® Recombinant Antibody for FC

Cat No. 98380-3-PBS

Clone No.242689E1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL15RA, CD215, IL 15 receptor subunit alpha, IL 15R alpha, IL 15RA

• 

  FC experiment of Human Monocytes using 98380-3-RR (same clone as 98380-3-PBS)

  1x10^6 untreated or LPS and IFN-γ treated human monocytes were surface stained with 0.25 ug Anti-Human IL-15RA Rabbit RecAb (98380-3-RR, Clone:242689E1) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD14. Cells were not fixed. This data was developed using the same antibody clone with 98380-3-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of Human Monocytes using 98380-3-RR (same clone as 98380-3-PBS)

  1x10^6 LPS and IFN-γ treated human PBMCs were surface stained with 0.25 ug Anti-Human IL15RA Rabbit RecAb (98380-3-RR, Clone: 242689E1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human IL15RA Rabbit RecAb (98380-3-RR, Clone: 242689E1) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98380-3-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

98380-3-PBS targets IL-15RA in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: interleukin 15 receptor, alpha
• Calculated Molecular Weight: 231 aa, 24 kDa
• GenBank Accession Number: BC107777
• Gene Symbol: IL-15RA
• Gene ID (NCBI): 3601
• RRID: AB_3746025
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q13261
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Interleukin-15 (IL-15) is a pleiotropic cytokine that plays an important role in both innate and adaptive immunity. IL-15 is mainly produced by activated monocytes, macrophages and dendritic cells, and is structurally similar to IL-2 (PMID: 8178155; 12401478). These two cytokines share the same IL-2/15Rβ and common γ-chain receptor subunits. In addition, IL-2 and IL-15 have their own private α-chain receptor subunit, IL-2Rα and IL-15Rα, respectively (PMID: 7641685). The IL-15Rα chain is expressed by many cell types including monocytes, DCs, NK, T cells and fibroblasts. Several isoforms of IL-15Rα exist and are generated either by alternative splicing or by proteolytic cleavage (PMID: 10480910; 15265897).