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Anti-Mouse IL-17C Rabbit Recombinant Antibody, PBS Only (98556-1-PBS)

Anti-Mouse IL-17C Rabbit Recombinant Antibody, PBS Only

Name: Anti-Mouse IL-17C Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98556-1-PBS-1MG

IL-17C Uni-rAb^® Recombinant Antibody for FC (Intra)

Cat No. 98556-1-PBS

Clone No. 250601C2

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Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC (Intra)

Synonyms

Cytokine CX2, Il 17c, Il17c, Interleukin-17C

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

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Filter: AllFC (Intra)Affinity

FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)
1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.
FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)
1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.
Affinity and Kinetic Characterization of 98556-1-RR
Biolayer interferometry (BLl) kinetic assays of 98556-1-RR against Mouse IL-17C were performed. The affinity constant is 1.83 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Overview

Tested Applications
Product Information

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Product Information

98556-1-PBS targets IL-17C in FC (Intra) applications and shows reactivity with mouse samples.

Tested Reactivity	mouse
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg2840 Product name: Recombinant Mouse IL-17C protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 15-194 aa of NM_145834.3 Sequence: HQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ Predict reactive species
Full Name	interleukin 17C
Calculated Molecular Weight	22 kDa
GenBank Accession Number	NM_145834.3
Gene Symbol	Il17c
Gene ID (NCBI)	234836
RRID	AB_3746176
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	Q8K4C5
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

IL-17C is a member of the IL-17 cytokine family, was cloned from a human fetal kidney library in 2000 (PMID: 10639155). The IL-17 family comprises at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464). IL-17C is selectively induced in epithelia by bacterial challenge and inflammatory stimuli (PMID: 21993848). IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection (PMID: 21993849).