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IL-17F Monoclonal antibody, PBS Only

IL-17F Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

6H5F10

Cat no : 60245-1-PBS

Synonyms

Cytokine ML 1, IL 17F, IL17F, IL-17F, interleukin 17F, ML 1, ML1

Validation Data Gallery

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  • Western Blot (WB) analysis of human brain tissue using IL-17F Monoclonal antibody (60245-1-Ig)

    WB analysis of human brain using 60245-1-Ig (same clone as 60245-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 60245-1-Ig (IL-17F antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60245-1-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

60245-1-PBS targets IL-17F in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen IL-17F fusion protein Ag16310
Full Name interleukin 17F
Calculated Molecular Weight 163 aa, 18 kDa
Observed Molecular Weight 37 kDa
GenBank Accession NumberBC070124
Gene Symbol IL17F
Gene ID (NCBI) 112744
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 family plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. IL-17F shares the highest homology with IL-17A and signals via a receptor composed by the IL-17RA and IL-17RC subunits. IL-17A and IL-17F can form IL-17A/A or IL-17F/F homodimers, IL-17A/F heterodimers are also formed. IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. IL-17F levels are elevated in sera and lesional psoriatic skin compared to non-lesional tissue. IL-17F also has been implicated in the development of neutrophilic airway inflammation.