Anti-Mouse IL-17RA Rabbit Recombinant Antibody, PBS Only

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• Anti-Mouse IL-17RA Rabbit Recombinant Antibody, PBS Only (98532-2-PBS)

IL-17RA Uni-rAb^® Recombinant Antibody for FC

Cat No. 98532-2-PBS Copied!

Clone No. 250349C6

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Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

CD217, IL-17 receptor A, Il17r, Il17ra, Interleukin-17 receptor A

• 

  FC experiment of mouse bone marrow cells using 98532-2-RR (same clone as 98532-2-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-17RA Rabbit RecAb (98532-2-RR, Clone: 250349C6) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Mouse Ly-6G/Ly-6C (Gr-1). Cells were not fixed. This data was developed using the same antibody clone with 98532-2-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of mouse bone marrow cells using 98532-2-RR (same clone as 98532-2-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-17RA Rabbit RecAb (98532-2-RR, Clone: 250349C6) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98532-2-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

98532-2-PBS targets IL-17RA in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2584

  Product name: Recombinant Mouse IL-17RA protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 32-322 aa of NM_008359.2

  Sequence: SPRLLDFPAPVCAQEGLSCRVKNSTCLDDSWIHPKNLTPSSPKNIYINLSVSSTQHGELVPVLHVEWTLQTDASILYLEGAELSVLQLNTNERLCVKFQFLSMLQHHRKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKIIFVPDCEDSKMKMTTSCVSSGSLWDPNITVETLDTQHLRVDFTLWNESTPYQVLLESFSDSENHSCFDVVKQIFAPRQEEFHQRANVTFTLSKFHWCCHHHVQVQPFFSSCLNDCLRHAVTVPCPVISNTTVPKPVADYIPLW

• Full Name: interleukin 17 receptor A
• Calculated Molecular Weight: 98kDa
• GenBank Accession Number: NM_008359.2
• Gene Symbol: Il17ra
• Gene ID (NCBI): 16172
• RRID: AB_3746159
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q60943
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

IL-17 is a proinflammatory cytokine. IL-17 can signal as homodimers or heterodimers through a heterodimeric receptor formed by IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC) subunits. IL-17RA is ubiquitously expressed in both the epithelial and hematopoietic cell compartments. IL-17/IL-17RA signaling plays an important physiological role in regulating the mucosal host defense against invading microorganisms, but it can also play pathogenic roles in several inflammatory or autoimmune conditions; furthermore, it has been described as pro-tumorigenic in several cancer types.