Anti-Human IL-23R Rabbit Recombinant Antibody, PBS Only

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  FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

  1x10^6 HEK-293T cells or IL-23R-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

  1x10^6 HEK-293T cells (left) or IL-23R-transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) (red) or Isotype Control (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98180-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98180-1-RR against Human IL-23R were performed. The affinity constant is 2.83 nM.

IL-23R Uni-rAb^® Recombinant Antibody for FC

Cat No. 98180-1-PBS

Clone No.240905B5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL23R, interleukin 23 receptor, IL-23 receptor, IL 23R, IL 23 receptor

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Product Information

98180-1-PBS targets IL-23R in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: interleukin 23 receptor
• Calculated Molecular Weight: 72 kDa
• GenBank Accession Number: NM_144701.3
• Gene Symbol: IL-23R
• Gene ID (NCBI): 149233
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q5VWK5-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).