IL-11 Polyclonal antibody

• 

  WB analysis of human plasma using 55169-1-AP

  human plasma were subjected to SDS PAGE followed by western blot with 55169-1-AP (IL11 antibody) at dilution of 1:1000 incubated at 4 degree celsius over night.

• Featured Product
• KD/KO Validated

IL-11 Polyclonal Antibody for WB, ELISA

Cat No. 55169-1-AP

Publications(10)

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, ELISA

Synonyms

IL11, Adipogenesis inhibitory factor, AGIF, IL 11, interleukin 11

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Tested Applications

• Positive WB detected in: human plasma tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 2 publications below
• WB: See 8 publications below
• IHC: See 3 publications below

Product Information

55169-1-AP targets IL-11 in WB, IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human, mouse, monkey
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: interleukin 11
• Calculated Molecular Weight: 21 kDa
• Observed Molecular Weight: 25 kDa
• GenBank Accession Number: NM_000641
• Gene Symbol: IL-11
• Gene ID (NCBI): 3589
• RRID: AB_2881280
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P20809
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IL-11 is a member of the interleukin family of cytokines. It was discovered in the late 20th century as researchers were exploring various cytokines involved in immune responses and cell growth regulation. IL-11 has significant effects on hematopoietic cells. It can stimulate the proliferation and differentiation of megakaryocytes, which are the precursors of platelets. This action helps in the regulation of platelet production.

Publications

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
mouse	WB	Nat Commun; ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice; Authors - Tao Zhuang
mouse,human	WB,IHC	Sci Adv; Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.; Authors - Xin Bai ; KD Validated
mouse,human	IHC	Life Sci; The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis; Authors - Ling-Feng Jiang
mouse	WB	Ecotoxicol Environ Saf; Carbon disulfide induced decidualization disorder in the mice uterus at the window of implantation.; Authors - Fengyan Huang
monkey	WB	Vet Res; Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection.; Authors - Yuchen Li ; KD Validated
mouse	WB	Theranostics; IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer; Authors - Qian Zhao