Tested Applications
| Positive WB detected in | human plasma tissue, human plasma, rat plasma |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
55169-1-AP targets IL-11 in WB, IHC, IF, ELISA applications and shows reactivity with human, rat samples.
| Tested Reactivity | human, rat |
| Cited Reactivity | human, mouse, rat, monkey |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | interleukin 11 |
| Calculated Molecular Weight | 21 kDa |
| Observed Molecular Weight | 25 kDa |
| GenBank Accession Number | NM_000641 |
| Gene Symbol | IL-11 |
| Gene ID (NCBI) | 3589 |
| RRID | AB_2881280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P20809 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
IL-11 is a member of the interleukin family of cytokines. It was discovered in the late 20th century as researchers were exploring various cytokines involved in immune responses and cell growth regulation. IL-11 has significant effects on hematopoietic cells. It can stimulate the proliferation and differentiation of megakaryocytes, which are the precursors of platelets. This action helps in the regulation of platelet production.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for IL-11 antibody 55169-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The anti-IL-11 antibody (Cat# 55169-1-AP) has 18 citations. Publications appear in journals including Cell Metabolism, Nature Communications, ACS Nano, Theranostics, Advanced Science, Science Advances, Developmental Cell, British Journal of Pharmacology, Biochemical Pharmacology, Life Sciences, Scientific Reports, Cancers, Veterinary Research, Gland Surgery, Advanced Healthcare Materials, and Chinese Medical Journal. Research fields span fibrosis (pulmonary, cardiac, hepatic, renal), oncology (breast, lung, thyroid, liver cancer), immunology, lipid metabolism, antiviral responses, and wound healing.
| Species | Application | Title |
|---|---|---|
Cell Metab Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes. | ||
Nat Commun ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice | ||
Nat Commun Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy | ||
ACS Nano Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells | ||
Theranostics IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer | ||
Adv Sci (Weinh) Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape |
