IL-36RN Polyclonal antibody

IL-36RN Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 13113-1-AP

Synonyms

FIL1, FIL1 delta, FIL1(DELTA), FIL1D, IL 1 delta, IL 1 related protein 3, IL 1F5, IL 1HY1, IL 1L1, IL 1ra homolog 1, IL 1RP3, IL1F5, IL-1F5, IL1HY1, IL1L1, IL1RP3, IL-36Ra, IL-36RN, Interleukin 1 delta, Interleukin 1 family member 5, Interleukin 1 HY1, Interleukin 1 like protein 1

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Validation Data Gallery

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  IHC staining of human skin cancer using 13113-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 13113-1-AP (IL36RN antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human skin cancer using 13113-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 13113-1-AP (IL36RN antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human skin cancer using 13113-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 13113-1-AP (IL36RN antibody) at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human skin cancer using 13113-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 13113-1-AP (IL36RN antibody) at dilution of 1:200 (under 40x lens).

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Tested Applications

• Positive IHC detected in: human skin cancer tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• IHC: See 1 publications below

Product Information

13113-1-AP targets IL-36RN in IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: IL-36RN fusion protein Ag3780
• Full Name: interleukin 1 family, member 5 (delta)
• Calculated Molecular Weight: 155 aa, 17 kDa
• GenBank Accession Number: BC024747
• Gene Symbol: IL-36RN
• Gene ID (NCBI): 26525
• RRID: AB_2877917
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IL36RN is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). It inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling.

Publications

Species	Application	Title
human	IHC	PLoS One; Gene signatures associated with barrier dysfunction and infection in oral lichen planus identified by analysis of transcriptomic data; Authors - Phuc Thi-Duy Vo