Product Information
10651-1-AP targets Inhibin Beta A in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag1001 Product name: Recombinant human INHBA protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 126-426 aa of BC007858 Sequence: FAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS Predict reactive species |
| Full Name | inhibin, beta A |
| Calculated Molecular Weight | 47 kDa |
| Observed Molecular Weight | 42 kDa |
| GenBank Accession Number | BC007858 |
| Gene Symbol | Inhibin beta A |
| Gene ID (NCBI) | 3624 |
| RRID | AB_2125851 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P08476 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Inhibin is a 32-kD dimeric glycoprotein consisting of an alpha subunit and one of two beta subunits (beta A or beta B) leading to inhibin A or B, respectively, which was isolated and cloned on the basis of its ability to inhibit FSH release from the pituitary. Inhibin beta A forms a disulfide-linked homo-dimer known as activin A, which has been implicated in multiple biologic processes, including neoplastic progression. The inhibin beta A can also bind the beta B and A isoforms to form activin AB and inhibin, respectively.
Publications
What published studies show
The INHBA antibody (Cat# 10651-1-AP) has 21 citations across 19 journals including Nature Communications, Cell Death & Disease, British Journal of Cancer, Development, BMC Cancer, Theriogenology, and PLoS ONE. Research fields span oncology (colorectal, thyroid, gastric, esophageal, ovarian, head and neck cancers), TGF-β/PI3K/AKT signaling, EMT, reproductive biology (granulosa/Sertoli cell development, PCOS), neurodevelopment (myelination), fibrosis, and hepatocyte biology. Applications include WB, IHC, and IF.
| Species | Application | Title |
|---|---|---|
Nat Commun Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation. | ||
Cell Death Dis Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction.
| ||
J Transl Med A dynamic molecular landscape in colorectal cancer progression at single-cell resolution | ||
Int J Mol Med Molecular mechanisms and clinicopathological characteristics of inhibin βA in thyroid cancer metastasis | ||
Br J Cancer INHBA, regulated by C/EBPβ, induces M2 macrophage polarization to promote tumor metastasis and growth via activating the PI3K/AKT pathway in gastric cancer. | ||
Cells Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. |
