|Positive WB detected in||HeLa cells, HepG2 cells|
|Positive IP detected in||HeLa cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Sample-dependent, check data in validation data gallery|
The immunogen of 24819-1-AP is INO80 Fusion Protein expressed in E. coli.
|Host / Isotype||Rabbit / IgG|
|Immunogen||INO80 fusion protein Ag20309|
|Full Name||INO80 homolog (S. cerevisiae)|
|Calculated molecular weight||1556 aa, 177 kDa|
|Observed molecular weight||177 kDa, 150 kDa|
|GenBank accession number||BC146785|
|Gene ID (NCBI)||54617|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
DNA helicase INO80, also namd as INO80 or hINO80, is a 1,556 amino acid protein, which contains one helicase C-terminal domain, one helicase ATP-binding domain, and one DBINO domain. INO80 co-localizes with PCMA at replication forks during S-phase in the nucleus and belongs to the SNF2 helicase family. INO80 is a component of the chromatin remolding INO80 complex and is widely expressed in many tissues, such as brain,liver and pancreas. INO80 is involved in transcription regulation.
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.
INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.
J Allergy Clin Immunol
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.