CXCR2 Polyclonal antibody

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• CXCR2 Polyclonal antibody (19538-1-AP)

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  IHC staining of mouse spleen using 19538-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 19538-1-AP (Il8rb-Specific antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of mouse spleen using 19538-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 19538-1-AP (Il8rb-Specific antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CXCR2 Polyclonal Antibody for IHC, ELISA

Cat No. 19538-1-AP

Publications(5)

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

IHC, IF, ELISA

Synonyms

Cxcr2-Specific, CXCR-2, CXC-R2, C-X-C chemokine receptor type 2, Cmkar2

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Tested Applications

• Positive IHC detected in: mouse spleen tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• IHC: See 3 publications below
• IF: See 2 publications below

Product Information

19538-1-AP targets CXCR2 in IHC, IF, ELISA applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Cited Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: interleukin 8 receptor, beta
• Calculated Molecular Weight: 41 kDa
• GenBank Accession Number: NM_009909
• Gene Symbol: Cxcr2
• Gene ID (NCBI): 12765
• RRID: AB_2878587
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P35343
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CXCR2, also named as Cmkar2, Gpcr16, Il8rb or CD182, belongs to the G-protein coupled receptor 1 family. CXCR2 is a receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. CXCR2 binds to IL-8 with high affinity. CXCR2 also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. This antibody is specific to mouse CXCR2.

Publications

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
mouse	IF	Front Cell Dev Biol; Screening for novel factors involved in mouse early embryonic development using inhibitor libraries.; Authors - Hirofumi Nishizono
mouse	IF	Adv Sci (Weinh); Single-Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression; Authors - Rong Shen
mouse	IHC	Int Immunopharmacol; NGR-modified cancer-associated fibroblast-derived exosomes deliver resveratrol to inhibit CXCR2/NF-κB signaling in myeloid-derived suppressor cells and reverse immune suppression in liver cancer.; Authors - Lijuan Ding
mouse	IHC	Adv Sci (Weinh); The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP-1 Signaling in Colorectal Cancer.; Authors - Zhibo Hu
mouse	IHC	Adv Sci (Weinh); Tumor Microenvironment Responsive CD8+ T Cells and Myeloid-Derived Suppressor Cells to Trigger CD73 Inhibitor AB680-Based Synergistic Therapy for Pancreatic Cancer; Authors - Qiangda Chen