Integrin alpha 11 Recombinant monoclonal antibody

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  WB analysis using 84695-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 84695-1-RR (Integrin alpha 11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Integrin alpha 11 Recombinant Antibody for WB, ELISA

Cat No. 84695-1-RR

Clone No.241351B7

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

ITGA11, Integrin alpha-11, 241351B7

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Tested Applications

• Positive WB detected in: SH-SY5Y cells, Neuro-2a cells, HeLa cells, A549 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

84695-1-RR targets Integrin alpha 11 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: integrin, alpha 11
• Calculated Molecular Weight: 133 kDa
• Observed Molecular Weight: 170 kDa
• GenBank Accession Number: NM_001004439
• Gene Symbol: ITGA11
• Gene ID (NCBI): 22801
• RRID: AB_3672111
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q9UKX5
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 11 (ITGA11) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen. This receptor is involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells (PMID: 11518510). It is also involved in the regulation of myofibroblast phenotypic differentiation during fibrotic diseases (PMID: 29147013).