Integrin beta 4 Recombinant monoclonal antibody, PBS Only

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  WB analysis using 87416-2-RR (same clone as 87416-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 87416-2-RR (ITB4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87416-2-PBS in a different storage buffer formulation.

• 

  Affinity of 87416-2-RR

  Biolayer interferometry (BLl) kinetic assays of 87416-2-RR against Human Integrin beta 4 were performed. The affinity constant is 6.72 nM.

Integrin beta 4 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 87416-2-PBS

Clone No.252740B3

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

ITGB4, CD104, GP150, Integrin beta-4, integrin, beta 4

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Product Information

87416-2-PBS targets Integrin beta 4 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg10479

  Product name: Recombinant human ITB4 protein

  Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

  Tag: C-Twin-Strep-Tag

  Domain: 10011436 of

  Sequence: \

• Full Name: integrin, beta 4
• Observed Molecular Weight: 200 kDa
• Gene Symbol: Integrin beta 4
• Gene ID (NCBI): 3691
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.