Product Information
88294-1-PBS targets JAK1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag25579 Product name: Recombinant human JAK1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1080-1151 aa of BC132729 Sequence: SDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEA Predict reactive species |
| Full Name | Janus kinase 1 (a protein tyrosine kinase) |
| Calculated Molecular Weight | 1154 aa, 133 kDa |
| Observed Molecular Weight | 125-133 kDa |
| GenBank Accession Number | BC132729 |
| Gene Symbol | JAK1 |
| Gene ID (NCBI) | 3716 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P23458 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Janus kinase 1(JAK1), is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 is essential for signaling for certain type I and type II cytokines. JAK1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
