Product Information
20038-1-AP targets KDM4B in ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | lysine (K)-specific demethylase 4B |
| Calculated Molecular Weight | 122 kDa |
| GenBank Accession Number | NM_015015 |
| Gene Symbol | KDM4B |
| Gene ID (NCBI) | 23030 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O94953 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
KDM4B, also named as JHDM3B, JMJD2B and KIAA0876, belongs to the JHDM3 histone demethylase family. KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. KDM4B is able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. The antibody recognizes near the C-term of KDM4B and has no cross reaction to KDM4A.
