Product Information
31847-1-PBS targets CEP104 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag35662 Product name: Recombinant human KIAA0562 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-200 aa of NM_014704.3 Sequence: MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDL Predict reactive species |
| Full Name | KIAA0562 |
| Calculated Molecular Weight | 104kDa，925aa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | NM_014704.3 |
| Gene Symbol | KIAA0562 |
| Gene ID (NCBI) | 9731 |
| RRID | AB_3742485 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | O60308 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
KIAA0562, also known as CEP104 (centrosomal protein 104), is a gene encoding a centrosomal protein that is essential for ciliogenesis and the structural integrity of the cilium tip. During ciliogenesis, CEP104 is translocated from the distal tip of the centriole to the elongated cilium tip. CEP104 is expressed in a variety of cell types, including tissues such as testis and kidney. Mutations in its gene are associated with the autosomal recessive disorder Joubert syndrome, which is characterized by distinctive mid-hindbrain and cerebellar malformations, actinic dyskinesia, irregular breathing, developmental delay, and ataxia. In studies, inhibitors of CEP104 such as Cytochalasin D and Vismodegib have been used to investigate their specific role in cellular function.
