KIF14 Recombinant antibody, PBS Only

• 

  WB analysis using 85707-1-RR (same clone as 85707-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85707-1-RR (KIF14 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85707-1-PBS in a different storage buffer formulation.

KIF14 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 85707-1-PBS

Clone No.243005B8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

Kinesin-like protein KIF14

---

Product Information

85707-1-PBS targets KIF14 in applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: KIF14 fusion protein Ag23219
• Full Name: kinesin family member 14
• Observed Molecular Weight: 186 kDa
• GenBank Accession Number: BC113742
• Gene Symbol: KIF14
• Gene ID (NCBI): 9928
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q15058
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

KIF14 (Kinesin Family Member 14) is a microtubule-based motor protein belonging to the kinesin-3 family. It plays essential roles during cell division and has been implicated in various biological processes, including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. KIF14 is highly conserved across species and is characterized by a catalytic motor domain that binds to microtubules and ATP, enabling it to convert chemical energy into mechanical work. KIF14 interacts with the Skp1/Cul1/F-box (SCF) complex, particularly Skp2 and Cks1, to regulate the ubiquitination and degradation of p27Kip1. Knockdown of KIF14 results in the accumulation of p27Kip1, leading to cell cycle arrest and apoptosis.(PMID: 34131133, PMID: 24854087)