Anti-Mouse KLRG1 (2F1) Armenian Hamster Recombinant Antibody, PBS Only

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• Anti-Mouse KLRG1 (2F1) Armenian Hamster Recombinant Antibody, PBS Only (65682-1-PBS)

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  FC experiment of mouse splenocytes using 65682-1-AR (same clone as 65682-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse KLRG1 (2F1) Armenian Hamster IgG2a RecAb (65682-1-AR, Clone:2F1), or Armenian Hamster IgG Isotype Control (PIP) (65210-1-Ig, Clone: PIP) and FITC-conjugated Anti-Armenian Hamster IgG antibody. Cells were then stained with CoraLite® Plus 647 Anti-Mouse NK1.1 (CD161). Cells were not fixed. This data was developed using the same antibody clone with 65682-1-PBS in a different storage buffer formulation.

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  FC experiment of human PBMCs using 65682-1-AR (same clone as 65682-1-PBS)

  1x10^6 human PBMCs were unstained or surface stained with 0.25 ug Anti-Mouse KLRG1 (2F1) Armenian Hamster RecAb (65682-1-AR, Clone:2F1), and FITC-conjugated Anti-Armenian Hamster IgG antibody. Cells were then stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56 Rabbit Recombinant Antibody (CL647-98033, Clone: 240078A7). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65682-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65682-1-AR (same clone as 65682-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Mouse KLRG1 (2F1) Armenian Hamster RecAb (65682-1-AR, Clone: 2F1 )(red) or unstained (blue), and FITC-conjugated Anti-Armenian Hamster IgG antibody. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65682-1-PBS in a different storage buffer formulation.

KLRG1 Uni-rAb^® Recombinant Antibody for FC

Cat No. 65682-1-PBS

Clone No.2F1

Host / Isotype

Armenian Hamster / IgG2a

Reactivity

human, mouse

Applications

FC

Synonyms

CLEC15A, Killer cell lectin-like receptor subfamily G member 1, MAFA, MAFAL, Mast cell function-associated antigen 2F1

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Product Information

65682-1-PBS targets KLRG1 in FC applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Armenian Hamster / IgG2a
• Class: Recombinant
• Type: Antibody
• Immunogen:

  N/A

• Full Name: killer cell lectin-like receptor subfamily G, member 1
• GenBank Accession Number: BC101953
• Gene Symbol: Klrg1
• Gene ID (NCBI): 50928
• RRID: AB_3743297
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O88713
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

KLRG1 (killer cell lectin-like receptor subfamily G, member 1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is expressed by subsets of NK and T cells, existing both as a monomer and as a disulfide-linked homodimer (PMID: 10741410; 19604491). It is considered to be a cell differentiation marker for NK and T cells and is strongly induced by viral and other infections (PMID: 20373518). Through interactions with members of the cadherin family, KLRG1 plays an inhibitory role on NK- and T-cell function (PMID: 19009530; 20373518).