LATS2-Specific Recombinant monoclonal antibody

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• LATS2-Specific Recombinant monoclonal antibody (88282-1-RR)

LATS2-Specific Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 88282-1-RR

Clone No.260670D9

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

LATS2, EC:2.7.11.1, KPM, LATS 2, Serine/threonine-protein kinase kpm

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  WB analysis using 88282-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 88282-1-RR (LATS2-Specific antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: HT-1080 cells, HeLa cells, HEK-293 cells, Jurkat cells, SGC-7901 cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

88282-1-RR targets LATS2-Specific in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: LATS, large tumor suppressor, homolog 2 (Drosophila)
• Calculated Molecular Weight: 120 kDa
• Observed Molecular Weight: 130-150 kDa
• GenBank Accession Number: NM_014572
• Gene Symbol: LATS2
• Gene ID (NCBI): 26524
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9NRM7
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

LATS2, also named as KPM, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. LATS2 is a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. It is a negative regulator of the androgen receptor. LATS2 has a calculated molecular mass of 120 kDa and an apparent molecular mass of 150 kDa (PMID: 10871863). The antibody is specific to LATS2.