Anti-Mouse LEPR Rabbit Recombinant Antibody, PBS Only

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• Anti-Mouse LEPR Rabbit Recombinant Antibody, PBS Only (98625-2-PBS)

LEPR Uni-rAb^® Recombinant Antibody for FC

Cat No. 98625-2-PBS

Clone No.250779C11

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

B219, CD295, Db, LEP-R, Leptin receptor

• 

  FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

  1x10^6 CHO cells or Lepr tansfected CHO cells were surface stained with 0.25 ug Anti-Mouse LEPR Rabbit RecAb (98625-2-RR, Clone:250779C11), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) , and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98625-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

  1x10^6 CHO cells or Lepr tansfected CHO cells were surface stained with 0.25 ug Anti-Mouse LEPR Rabbit RecAb (98625-2-RR, Clone:250779C11) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98625-2-PBS in a different storage buffer formulation.

• 

  Affinity of 98625-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98625-2-RR against Mouse LEPR were performed. The affinity constant is 5.30 nM.

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Product Information

98625-2-PBS targets LEPR in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2930

  Product name: Recombinant Mouse Lepr protein (rFc Tag) (HPLC verified)

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 22-839 aa of NM_146146.2

  Sequence: LNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAG

• Full Name: leptin receptor
• Calculated Molecular Weight: 131 kDa
• GenBank Accession Number: NM_146146.2
• Gene Symbol: Lepr
• Gene ID (NCBI): 16847
• RRID: AB_3746224
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P48356-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Leptin receptor (LEPR) is a protein-coding gene that encodes a receptor for leptin, an adipocyte-specific hormone that regulates body weight and fat metabolism (PMID: 11861497; 16333525). LEPR is involved in various physiological processes, including energy homeostasis, immune function, and hematopoiesis (PMID: 11923481; 25383904). It activates the JAK2/STAT3 signaling pathway, which is crucial for mediating leptin's effects on gene transcription and cellular responses (PMID: 11923481). LEPR also plays a role in the regulation of lipid metabolism, blood pressure, and blood glucose levels (PMID: 29254602).