Tested Applications
| Positive IHC detected in | human placenta tissue, human small intestine tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
17180-1-AP targets LETM2 in WB, IHC, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag10900 Product name: Recombinant human LETM2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-277 aa of BC029541 Sequence: MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDILVELPTFTESKENMVDLAPQLKGTKDEDFIQPPPVTSSPITPSTPISLPKGPITSSEEPTLQAKSQMTAQNSKASSKGA Predict reactive species |
| Full Name | leucine zipper-EF-hand containing transmembrane protein 2 |
| Calculated Molecular Weight | 277 aa, 31 kDa |
| GenBank Accession Number | BC029541 |
| Gene Symbol | LETM2 |
| Gene ID (NCBI) | 137994 |
| RRID | AB_2571737 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q2VYF4 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for LETM2 antibody 17180-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
LETM2 antibody (Cat# 17180-1-AP) has 5 citations across journals including J Transl Med, Am J Hum Genet, J Mol Med (Berl), Cancers (Basel), and Funct Integr Genomics. Research fields span gastric cancer prognostic modeling, esophageal squamous cell carcinoma structural variations, spinal muscular atrophy pathology via SUMOylation, pancreatic cancer PI3K-Akt signaling, and mitochondrial function/autophagy in diabetic foot ulcers. Applications include WB and IHC in human samples.
| Species | Application | Title |
|---|---|---|
J Transl Med Integrated multi-omics analysis and machine learning developed a prognostic model based on mitochondrial function in a large multicenter cohort for Gastric Cancer | ||
Am J Hum Genet Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma.
| ||
J Mol Med (Berl) Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology. | ||
Cancers (Basel) A LETM2-Regulated PI3K-Akt Signaling Axis Reveals a Prognostic and Therapeutic Target in Pancreatic Cancer | ||
Funct Integr Genomics LETM2 regulates mitochondrial function and autophagy in diabetic foot ulcers: implications for oxidative stress and therapeutic targeting.
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