LONP2 Recombinant monoclonal antibody, PBS Only

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  WB analysis using 86291-2-RR (same clone as 86291-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86291-2-RR (LONP2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86291-2-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 86291-2-RR

  Biolayer interferometry (BLl) kinetic assays of 86291-2-RR against Human LONP2 were performed. The affinity constant is 0.636 nM.

LONP2 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 86291-2-PBS

Clone No.251061E10

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

EC:3.4.21.53, Lon protease 2, Lon protease homolog 2, peroxisomal, Lon protease-like protein 2, LONP

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Product Information

86291-2-PBS targets LONP2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag12650

  Product name: Recombinant human LONP2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 503-852 aa of BC093910

  Sequence: DRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGCREHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLLNSKL

• Full Name: lon peptidase 2, peroxisomal
• Calculated Molecular Weight: 852 aa, 95 kDa
• Observed Molecular Weight: 95 kDa
• GenBank Accession Number: BC093910
• Gene Symbol: LONP2
• Gene ID (NCBI): 83752
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q86WA8
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

LONP2 (Lon Peptidase 2, Peroxisomal) is an important ATP-dependent protease. It is primarily located in peroxisomes and is responsible for maintaining the proteostasis of this organelle. By degrading misfolded proteins and selectively regulating metabolic enzymes, LONP2 plays a central role in maintaining peroxisomal proteostasis and metabolic balance. Dysfunction of LONP2 is closely related to a variety of human diseases, including peroxisomal disorders, cancer, and neurodegenerative diseases.