|Positive WB detected in||A549 cells, human placenta tissue, A375 cells, human heart tissue|
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:1000-1:4000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
67139-1-Ig targets LOXL2 in WB, IF, ELISA applications and shows reactivity with Human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||LOXL2 fusion protein Ag28566|
|Full Name||lysyl oxidase-like 2|
|Calculated molecular weight||774 aa, 87 kDa|
|Observed molecular weight||100 kDa|
|GenBank accession number||BC000594|
|Gene ID (NCBI)||4017|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
LOXL2, also named as WS9-14, belongs to an amine oxidase family whose members have been implicated in crosslink formation in stromal collagens and elastin, cell motility, and tumor development and progression. LOXL2 activity might be a crucial modulator of Snail, providing an additional control mechanism of EMT and tumor progression. Increased LOXL2 expression in colon and esophageal cancer may contribute to tumor progression. We detected a band about 100 kd which is a secretory mature LOXL2 protein modified by glycosylation (PMID: 24014025).
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.
Int J Biol Macromol
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia.
METTL1/WDR4-mediated tRNA m7G modification and mRNA translation control promote oncogenesis and doxorubicin resistance
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Boyan (Verified Customer) (10-04-2021)
The calculated MW is 87 kd. This antibody recognized major bands at 65, and 60 kd.