LRRK2 Polyclonal antibody
LRRK2 Polyclonal Antibody for IF, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
IF, ELISA
Conjugate
Unconjugated
Cat no : 55497-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF detected in | SH-SY5Y cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF) | IF : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
55497-1-AP targets LRRK2 in IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | leucine-rich repeat kinase 2 |
| Calculated Molecular Weight | 286 kDa |
| GenBank Accession Number | NM_198578 |
| Gene Symbol | LRRK2 |
| Gene ID (NCBI) | 120892 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
LRRK2, also termed Dardarin and PARK8, belongs to the protein kinase superfamily and TKL Ser/Thr protein kinase family. It is a protein kinase whose role is not yet known. LRRK2 may play a role in the phosphorylation of proteins central to Parkinson disease. It may also have GTPase activity (PMID:16352719). Defects in LRRK2 are the causes of Parkinson disease type 8 (PARK8). This antibody is specific to LRRK2.
