LUC7L2 Polyclonal antibody, PBS Only

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• LUC7L2 Polyclonal antibody, PBS Only (24202-1-PBS)

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  WB analysis of K-562 using 24202-1-AP (same clone as 24202-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

  WB result of LUC7L2 antibody (24202-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LUC7L2 transfected HeLa cells. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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  IF Staining of A431 using 24202-1-AP (same clone as 24202-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A431 cells using LUC7L2 antibody (24202-1-AP) at dilution of 1:600 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

LUC7L2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 24202-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

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Product Information

24202-1-PBS targets LUC7L2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag21135

  Product name: Recombinant human LUC7L2 protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 1-392 aa of BC017163

  Sequence: MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI

• Full Name: LUC7-like 2 (S. cerevisiae)
• Calculated Molecular Weight: 392 aa, 47 kDa
• Observed Molecular Weight: 46 kDa
• GenBank Accession Number: BC017163
• Gene Symbol: LUC7L2
• Gene ID (NCBI): 51631
• RRID: AB_2879455
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• UNIPROT ID: Q9Y383
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing, and promoted its nonsense-mediated decay, leading to its downregulation at the protein level (PMID:34155193). Moreover, LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing (PMID:33961773).