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MAPKAP1 Polyclonal antibody

MAPKAP1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

ELISA

Conjugate

Unconjugated

Cat no : 20993-1-AP

Synonyms

JC310, MAPKAP1, MIP1, mSIN1, SAPK interacting protein 1, SIN1, SIN1b, SIN1g, TORC2 subunit MAPKAP1

Validation Data Gallery

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

20993-1-AP targets MAPKAP1 in ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name mitogen-activated protein kinase associated protein 1
Calculated Molecular Weight 59 kDa
GenBank Accession NumberNM_024117
Gene Symbol MAPKAP1
Gene ID (NCBI) 79109
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

MAPKAP1, also named as MIP1 and SIN1, belongs to the SIN1 family. It is a subunit of mTORC2 which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. It inhibits HRAS and KRAS signaling. MAPKAP1 enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. The antibody is specific to MAPKAP1. The antibody can recognize all the isoform of MAPKAP1.