Product Information
98044-1-PBS targets MCP-1/CCL2 in FC (Intra) applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg31375 Product name: Recombinant Human MCP-1/CCL2 protein (Myc Tag, His Tag) Source: mammalian cells-derived, pHZ-KIsec Tag: Myc & 6*His Domain: 24-99 aa of BC009716 Sequence: QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT Predict reactive species |
| Full Name | chemokine (C-C motif) ligand 2 |
| Calculated Molecular Weight | 99 aa, 11 kDa |
| GenBank Accession Number | BC009716 |
| Gene Symbol | MCP-1/CCL2 |
| Gene ID (NCBI) | 6347 |
| RRID | AB_3672191 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P13500 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a chemokine that regulates monocyte and macrophage migration and infiltration. In addition to monocytes and macrophages, MCP-1 can also serve as a chemoattractant for T cells, B cells, NK cells, dendritic cells, and neutrophils. MCP-1 expression is typically induced by the release of inflammatory cytokines and other stimuli from sites of tissue injury and infection. It in turn promotes the extravasation of immune cells across blood vessel walls and their subsequent infiltration of the infection site. It may also play a role in macrophage polarization as well as the differentiation of monocytes into dendritic cells, MSDCs, and osteoclasts. Increased MCP-1 expression has been linked to inflammatory diseases such as rheumatoid arthritis, atherosclerosis, and multiple sclerosis. (PMID: 19441883, 31921102)
