MDM2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66511-1-Ig |CloneNo.: 2A6C9

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Freight/Packing

Con: 150 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
Human, mouse, rat

Positive WB detected in:
MCF-7 cells,A549 cells, rat brain tissue, mouse brain tissue

Recommended dilution:
WB : 1:1000-1:6000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
Mdm2 p53 binding protein homolog (mouse)

Calculated molecular weight:
55 kDa

Observed molecular weight:
40-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MDM2

Synonyms
Double minute 2 protein, hdm2, HDMX, MDM2, Oncoprotein Mdm2, p53 binding protein Mdm2
Background

MDM2 belongs to the MDM2/MDM4 family. It inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. MDM2 can bind to the p53 tumor suppressor protein and negatively regulate its functions in transcription, cell cycle arrest, and apoptosis. Human mdm2 has a calculated molecular mass of 54 kDa.


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