Product Information
87618-1-PBS targets MED13L in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | mediator complex subunit 13-like |
| Calculated Molecular Weight | 243 kDa |
| Observed Molecular Weight | 270 kDa |
| GenBank Accession Number | NM_015335 |
| Gene Symbol | MED13L |
| Gene ID (NCBI) | 23389 |
| RRID | AB_3745653 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q71F56 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
MED13L, also named as KIAA1025, PROSIT240, THRAP2 and TRAP240L, belongs to the Mediator complex subunit 13 family. It is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. MED13L is a mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. MED13L is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
