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  • KD/KO Validated

MGP Polyclonal antibody

MGP Polyclonal Antibody for IF, IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 10734-1-AP

Synonyms

GIG36, matrix Gla protein, MGLAP, MGP, NTI



Tested Applications

Positive IHC detected inhuman breast hyperplasia tissue, human breast cancer tissue, human colon cancer tissue, human lymphoma tissue, human small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inmouse kidney tissue

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:200-1:800
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

10734-1-AP targets MGP in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MGP fusion protein Ag1091
Full Name matrix Gla protein
Calculated molecular weight 103 aa, 13 kDa
GenBank accession numberBC005272
Gene symbol MGP
Gene ID (NCBI) 4256
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Matrix Gla protein (MGP), a vitamin K-dependent protein, is recognized as a calcification inhibitor in vascular tissue. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

Protocols

Product Specific Protocols
IHC protocol for MGP antibody 10734-1-APDownload protocol
IF protocol for MGP antibody 10734-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Cancer Manag Res

Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses.

Authors - Yong Wu
humanIHC

Mol Med Rep

Prognostic value of matrix Gla protein in breast cancer.

Authors - Yoshimura Keiko K
humanWB

Neurosci Lett

Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease.

Authors - Santa-Maria Ismael I
ratWB,IF

Urology

High concentration of calcium promotes mineralization in NRK52E cells via inhibiting the expression of matrix Gla protein.

Authors - Qing Wang
  • KD Validated
mouseIHC

Calcif Tissue Int

Characterization of dystrophic calcification induced in mice by cardiotoxin.

Authors - Zhao Yongdong Y
mouseWB,IF

Life Sci

Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program.

Authors - Sarafraz Ahmad
  • KD Validated