|Positive IHC detected in||human breast hyperplasia tissue, human breast cancer tissue, human colon cancer tissue, human lymphoma tissue, human small intestine tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:200-1:800|
|Sample-dependent, check data in validation data gallery|
10734-1-AP targets MGP in WB, IHC, IF,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||MGP fusion protein Ag1091|
|Full Name||matrix Gla protein|
|Calculated molecular weight||103 aa, 13 kDa|
|GenBank accession number||BC005272|
|Gene ID (NCBI)||4256|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Matrix Gla protein (MGP), a vitamin K-dependent protein, is recognized as a calcification inhibitor in vascular tissue. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Cancer Manag Res
Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses.
Mol Med Rep
Prognostic value of matrix Gla protein in breast cancer.
Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease.
High concentration of calcium promotes mineralization in NRK52E cells via inhibiting the expression of matrix Gla protein.
Calcif Tissue Int
Characterization of dystrophic calcification induced in mice by cardiotoxin.
Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program.