Validation Data Gallery
|Positive IHC detected in
|human colon cancer tissue, human small intestine tissue, human breast cancer tissue, human lymphoma tissue, human breast hyperplasia tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in
|mouse kidney tissue
|IHC : 1:50-1:500
|IF : 1:50-1:500
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
10734-1-AP targets MGP in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|human, mouse, rat
|Host / Isotype
|Rabbit / IgG
|MGP fusion protein Ag1091
|matrix Gla protein
|Calculated molecular weight
|103 aa, 13 kDa
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Matrix Gla protein (MGP), a vitamin K-dependent protein, is recognized as a calcification inhibitor in vascular tissue. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis.
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation.
Aging (Albany NY)
Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1.
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice.
Int J Obes (Lond)
Using gene expression to predict the secretome of differentiating human preadipocytes.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Kenzo (Verified Customer) (08-29-2023)
This antibody worked pretty well for IF on mouse liver frozen sections.