Product Information
30102-1-PBS targets MMP24 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag31597 Product name: Recombinant human mmp24 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 419-602 aa of NM_006690 Sequence: EQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNA Predict reactive species |
| Full Name | matrix metallopeptidase 24 (membrane-inserted) |
| Calculated Molecular Weight | 73KD |
| Observed Molecular Weight | 55-58 kDa |
| GenBank Accession Number | NM_006690 |
| Gene Symbol | MMP24 |
| Gene ID (NCBI) | 10893 |
| RRID | AB_3086228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y5R2 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes, such as arthritis or metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP24 (MT5-MMP) is a membrane type matrix metalloproteinase attached to the cell membrane by a transmembrane domain (PMID: 30654475). MMP24 is mainly expressed in the nervous system, hippocampus, and cerebellum (PMID: 10727639,35177031). MMP24 may negatively regulate the aggressiveness of cancer cells under the stiff ECM environment during tumor progression (PMID: 32093160). MMP24 can be detected as 62-65 kDa and 55-58 kDa (PMID: 16495457,20942921,10622708).
