MOCS1 Polyclonal antibody

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• MOCS1 Polyclonal antibody (31550-1-AP)

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  WB analysis using 31550-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 31550-1-AP (MOCS1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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  IF Staining of Jurkat using 31550-1-AP

  Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using MOCS1 antibody (31550-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

MOCS1 Polyclonal Antibody for WB, IF/ICC, ELISA

Cat No. 31550-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, ELISA

Synonyms

KIAA0381, MIG11, MOCOD, MOCS1A, MOCS1B

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Tested Applications

• Positive WB detected in: Jurkat cells, mouse liver tissue, rat liver tissue
• Positive IF/ICC detected in: Jurkat cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:6000
• Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

31550-1-AP targets MOCS1 in WB, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag35879

  Product name: Recombinant human MOCS1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 90-290 aa of NM_001075098

  Sequence: EEGVPLTPKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIVAQLQRLEGLRTIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAK

• Full Name: molybdenum cofactor synthesis 1
• Calculated Molecular Weight: 70kDa
• Observed Molecular Weight: 40-43 kDa
• GenBank Accession Number: NM_001075098
• Gene Symbol: MOCS1
• Gene ID (NCBI): 4337
• RRID: AB_3742448
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9NZB8
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

MOCS1 (Molybdenum cofactor synthesis 1), also known as MOCS1A, MOCS1B, MOCOD, plays a crucial role in the biosynthesis of molybdenum cofactor and molybdopterin, which are essential for the activity of several key enzymes involved in carbon, nitrogen, and sulfur metabolism. MOCS1 produces two functional proteins, MOCS1A and MOCS1B, which follow different translocation routes before mitochondrial matrix import for cPMP biosynthesis involving both proteins (PMID: 31996372). MOCS1 was tumor suppressor gene affecting survival positively, while the other genes were oncogenes whose high expression was associated with poor survival (PMID: 37120564). The MOCS1 protein exists multiple isoforms.