MRP2 Polyclonal antibody

MRP2 Polyclonal Antibody for IHC, WB,ELISA

Host / Isotype

Rabbit / IgG


human and More (1)





Cat no : 24893-1-AP



Tested Applications

Positive WB detected inHepG2 cells
Positive IHC detected inhuman small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

The immunogen of 24893-1-AP is MRP2 Fusion Protein expressed in E. coli.

Tested Reactivity human
Cited Reactivity human, monkey
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MRP2 fusion protein Ag18694
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Calculated molecular weight 1545 aa, 174 kDa
Observed molecular weight 190-250 kDa
GenBank accession numberBC136419
Gene symbol ABCC2
Gene ID (NCBI) 1244
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)


Product Specific Protocols
WB protocol for MRP2 antibody 24893-1-APDownload protocol
IHC protocol for MRP2 antibody 24893-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers.

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Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Authors - Hao Wang

J Virol Methods

Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.

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Anticancer Res

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The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


SHENG-FU (Verified Customer) (01-15-2018)

there were multiple bands on the membrane, and the band under 130 kDa were a high expression. But around 190 kDa -250 kDa there are a single band which might be the correct one.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:500
  • Cell Tissue Type: Rat primary astrocyte
MRP2 Antibody Western Blot, validation (1:500 dilution) in Rat primary astrocyte (Cat no:24893-1-AP)