MTUS1 Recombinant antibody, PBS Only

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  WB analysis using 85117-4-RR (same clone as 85117-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85117-4-RR (MTUS1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85117-4-PBS in a different storage buffer formulation.

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  IF Staining of PC-3 using 85117-4-RR (same clone as 85117-4-PBS)

  Immunofluorescent analysis of (4% PFA) fixed PC-3 cells using MTUS1 antibody (85117-4-RR, Clone: 242537B7 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 85117-4-PBS in a different storage buffer formulation.

MTUS1 Uni-rAb^TM Recombinant Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 85117-4-PBS

Clone No.242537B7

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

ATIP, ATBP, AT2 receptor-binding protein, AT2 receptor binding protein, Angiotensin-II type 2 receptor-interacting protein

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Product Information

85117-4-PBS targets MTUS1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: MTUS1 fusion protein Ag4242
• Full Name: mitochondrial tumor suppressor 1
• Calculated Molecular Weight: 51 kDa, 141 kDa
• Observed Molecular Weight: 50 kDa
• GenBank Accession Number: BC033842
• Gene Symbol: MTUS1
• Gene ID (NCBI): 57509
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9ULD2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706).