Anti-Human MUC1/CA15-3 Rabbit Recombinant Antibody, PBS Only

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• Anti-Human MUC1/CA15-3 Rabbit Recombinant Antibody, PBS Only (98901-1-PBS)

MUC1/CA15-3 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98901-1-PBS

Clone No.261143A1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CA153, CA15-3, MUC1, Breast carcinoma-associated antigen DF3, CA 15-3

• 

  FC experiment of human PBMCs using 98901-1-RR (same clone as 98901-1-PBS)

  1x10^6 untreated or PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human MUC1/CA15-3 Rabbit RecAb (98901-1-RR, Clone: 261143A1) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98901-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98901-1-RR (same clone as 98901-1-PBS)

  1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human MUC1/CA15-3 Rabbit RecAb (98901-1-RR, Clone: 261143A1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human MUC1/CA15-3 Rabbit RecAb (98901-1-RR, Clone:261143A1) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98901-1-PBS in a different storage buffer formulation.

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Product Information

98901-1-PBS targets MUC1/CA15-3 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  unknow

• Full Name: mucin 1, cell surface associated
• Gene Symbol: MUC1/CA15-3
• Gene ID (NCBI): 4582
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P15941
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MUC1 is a type I transmembrane glycoprotein expressed by various epithelial cells of the female reproductive tract, lung, breast, kidney, stomach, and pancreas. MUC1 is transcribed as a large precursor gene product, and upon translation, is cleaved in the endoplasmic reticulum, yielding two subunits: the large extracellular N-terminal subunit (MUC1-N, about 120-200 kDa) and the small cytoplasmic C-terminal subunit (MUC1-C, about 23-30 kDa). Among the known mucins, MUC1 is best studied and plays crucial roles in regulating many cellular properties, including cell proliferation, apoptosis, adhesion, and invasion. MUC1 is overexpressed in a wide range of human epithelial malignancies.