MVK Monoclonal antibody, PBS Only

• 

  WB analysis using 67820-1-Ig (same clone as 67820-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67820-1-Ig (MVK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67820-1-PBS in a different storage buffer formulation.

• 

  WB analysis of U2OS using 67820-1-Ig (same clone as 67820-1-PBS)

  U2OS cells were subjected to SDS PAGE followed by western blot with 67820-1-Ig (MVK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67820-1-PBS in a different storage buffer formulation.

MVK Monoclonal Antibody for WB, Indirect ELISA

Cat No. 67820-1-PBS

Clone No.2F1D3

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, Indirect ELISA

Synonyms

FLJ96772, LRBP, mevalonate kinase, MK, MVK, MVLK

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Product Information

67820-1-PBS targets MVK in WB, Indirect ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag28887

  Product name: Recombinant human MVK protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-396 aa of BC016140

  Sequence: MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL

• Full Name: mevalonate kinase
• Calculated Molecular Weight: 396 aa, 42 kDa
• Observed Molecular Weight: 42 kDa
• GenBank Accession Number: BC016140
• Gene Symbol: MVK
• Gene ID (NCBI): 4598
• RRID: AB_2918583
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q03426
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MVK (Mevalonate kinase) is a 42 kDa cytoplasmic protein that belongs to the GHMP kinase family. Mevalonate kinase catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy and ataxia.