MYST2 Recombinant monoclonal antibody, PBS Only

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  WB analysis using 86486-1-RR (same clone as 86486-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86486-1-RR (MYST2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86486-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86486-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86486-1-RR against Human MYST2 were performed. The affinity constant is 1.94 nM.

MYST2 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 86486-1-PBS

Clone No.251386C9

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

EC:2.3.1.48, HBO1, HBOa, Histone acetyltransferase KAT7, KAT 7

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Product Information

86486-1-PBS targets MYST2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag4693

  Product name: Recombinant human MYST2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-370 aa of BC032640

  Sequence: MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEF

• Full Name: MYST histone acetyltransferase 2
• Calculated Molecular Weight: 611 aa, 71 kDa
• Observed Molecular Weight: 71-75 kDa
• GenBank Accession Number: BC032640
• Gene Symbol: MYST2
• Gene ID (NCBI): 11143
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O95251
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MYST2, also named as HBO1, HBOa MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, belongs to the MYST (SAS/MOZ) family. It specifically represses AR mediated transcription. MYST2 is a candidate oncogene. It enhances the anchorage-independent growth of breast cancer cells.(PMID:19372580) MYST2 is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. It is an important downstream molecule of ERa, and ERK1/2 signaling pathway may involved in the expression of HBO1 increased by E2.